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1) Make your adsense ads blend
Have your adsense ads blend with your background and overall color scheme of your site. It helps to improve the click through rates by a lot. You may think that contrasting colors works better as it more prominent, but research has proven otherwise. Do not try to force your ads on your visitors, they won’t click on it. So blend in your ads with the rest of your site.
2) Use more than one ad format
Have a number of different ad formats on your website. The two best converting ad formats in general according to google are:
1) 336×280 larger rectangle
2) 160×600 wide skyscraper